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Skype lets you connect to others via instant message, audio conferencing and video phone. It can also call regular phone lines from anywhere in the world. It's packaged as a portable app so you communicate on the go and it's in PortableApps.com Format so it can easily integrate with the PortableApps.com Suite. It's released as freeware for personal and business use.
Skype-to-Skype calls, video calls and instant messaging are free, any time of the day or night, anywhere in the world. Call phones and mobiles and send SMS messages at great value Pay As You Go rates, or call unlimited* to certain countries with a subscription.

* Free Skype-to-Skype calls.
* Call phones and mobiles, send SMS.
* Free instant messaging.
* Voicemail.
* Free video call.
* Forward calls to a phone when you’re offline.

sPortable can run from a cloud folder, external drive, or local folder without installing into Windows. It's even better with the PortableApps.com Platform for easy installs and automatic updates.